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Run the Wwise.exe from the proper Authoring\<platform>\bin folder.
To add OSP to a bus, create a new audio bus and place it under one of the master buses.

Click on the newly-created bus and then click on the Mixer Plug-in tab in the Audio Bus Property Editor. Select the >>, find the Oculus Spatializer selection, and add a Default (Custom) preset:


Under the Mixer Plug-in tab, click on the "…" button at the right-hand side of the property window. This will open up the Effect Editor (global properties) for OSP:
